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By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats.

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When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and induced a dose-dependent, naloxone-reversible antinociceptive effect following injection.

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The pupillary dilation that occurs following use of many antidepressant drugs including venlafaxine tablets may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patient iridectomy.

Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Pütz B, Binder EB, Müller-Myhsok B, Holsboer F (2008).

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Venlafaxine Extended Release Tablets (venlafaxine hydrochloride) are indicated for the treatment of major depressive disorder (MDD).

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The trials compared SSRIs with other SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline); SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine) with SSNRIs (duloxetine) and SNRIs (mirtazapine, venlafaxine); and SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, paroxetine), SNRIs (mirtazapine, venlafaxine), SSNRIs (duloxetine), and other second-generation antidepressants (bupropion, nefazodone) with other second-generation antidepressants (bupropion, nefazodone, trazodone).

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