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When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and induced a dose-dependent, naloxone-reversible antinociceptive effect following injection.
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The pupillary dilation that occurs following use of many antidepressant drugs including venlafaxine tablets may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patient iridectomy.
Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Pütz B, Binder EB, Müller-Myhsok B, Holsboer F (2008).
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The trials compared SSRIs with other SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline); SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine) with SSNRIs (duloxetine) and SNRIs (mirtazapine, venlafaxine); and SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, paroxetine), SNRIs (mirtazapine, venlafaxine), SSNRIs (duloxetine), and other second-generation antidepressants (bupropion, nefazodone) with other second-generation antidepressants (bupropion, nefazodone, trazodone).
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Numerous studies in vitro have failed to find a per se agonistic property of agmatine on these receptors (in line with the role of an allosteric modulator, which does not inhernetly act on the signalling of a receptor), while those in living models have noted that some effects of agmatine can be abolished with α2A receptor inhibitors ( and most commonly).
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